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Confirmatory factor analysis to assess the measure of adiposity that best fits the diagnosis of metabolic syndrome and relationship to physical activity in adults

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Abstract

Purpose

The objective of the study is to assess the goodness of fit for the diagnosis of metabolic syndrome in adults of four models with different measures of adiposity using confirmatory factor analysis, to develop a cardio metabolic risk index and to analyze its relationship to physical activity.

Methods

Cross-sectional descriptive multicenter study including 636 patients from the EVIDENT study. Considering as fixed variables, triglycerides/HDL-C ratio, HOMA-IR index and mean arterial pressure, we will compare which single-factor model of metabolic syndrome shows better goodness of fit. The models only differ by the measure of adiposity used: waist circumference, waist circumference/height, body mass index or adiposity index. With the factorial weights obtained, we created a quantitative metabolic index and analyzed its relationship to physical activity, quantified with the accelerometer for 1 week and measured at counts/min.

Results

The single-factor model including waist circumference in women and body mass index in men were those that were better indicators of goodness of fit. The estimated quantitative metabolic index shows a mean value in men of −0.022 ± 1.29 with a range of values between −3.36 and 4.57 and in women of 0.0001 ± 1.53 with a range of values between −3.17 and 5.55. The quantitative index shows an inverse relationship to physical activity.

Conclusions

Waist circumference in women and body mass index in men are the measures of adiposity that were better indicators goodness of fit. This quantitative index may be useful to quantify the risk of metabolic syndrome in clinical practice.

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Acknowledgments

This project was financed by the Carlos III Health Institute of the Ministry of Health in Spain (FIS: PS09/00233, PS09/01057, PS09/01972, PS09/01376, PS09/0164, PS09/01458, RETICS D06/0018) and Autonomous Government of Castilla and Leon (SAN/1778/2009).

Conflict of interest

None.

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Authors and Affiliations

Authors

Corresponding author

Correspondence to Manuel A. Gómez-Marcos.

Additional information

Trial Registration: Clinical Trials.gov Identifier: NCT01083082.

This study is conducted for EVIDENT Group.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 526 kb)

Appendix: All professionals participating in the EVIDENT study

Appendix: All professionals participating in the EVIDENT study

Coordinating center: Luis Garcia Ortiz, Manuel A Gómez Marcos, José I Recio Rodriguez and Carmen Patino Alonso of the Primary Care Research Unit of La Alamedilla Health Center, Salamanca. Spain.

Participating centers: La Alamedilla Health Center, Servicio de Salud de Castilla y León SACYL: Carmen Castaño Sánchez, Carmela Rodriguez Martín, Yolanda Castaño Sánchez, Cristina Agudo Conde, Emiliano Rodriguez Sánchez, Luis J Gonzalez Elena, Carmen Herrero Rodriguez, Benigna Sánchez Salgado, Angela de Cabo Laso and Jose A Maderuelo Fernández. Passeig de Sant Joan Health Centre, Servicio de Salud Catalan: Carlos Martín Cantera. Joan Canales Reina, Epifania Rodrigo de Pablo, Maria Lourdes Lasaosa Medina, Maria Jose Calvo Aponte, Amalia Rodriguez Franco, Elena Briones Carrio, Carme Martin Borras, Anna Puig Ribera and Ruben Colominas Garrido. Poble Sec Health Centre, Servicio de Salud Catalan: Juanjo Anton Alvarez, Mª Teresa Vidal Sarmiento, Ángela Viaplana Serra, Susanna Bermúdez Chillida, Aida Tanasa. Ca N’Oriac Health Centre, Servicio de Salud Catalan: Montserrat Romaguera Bosch. Sant Roc Health Centre, Servicio de Salud Catalan: Maria Mar Domingo, Anna Girona, Nuria Curos, Francisco Javier Mezquiriz, Laura Torrent. Cuenca III Health Centre, Servicio de Salud de Castilla-La Mancha SESCAM: Alfredo Cabrejas Sánchez, María Teresa Pérez Rodríguez, María Luz García García, Jorge Lema Bartolomé and Fernando Salcedo Aguilar. Casa de Barco Health Centre, Servicio de Salud de Castilla y León SACYL: Carmen Fernandez Alonso, Amparo Gómez Arranz, Elisa, Ibáñez Jalón, Aventina de la Cal de la Fuente, Natalia Gutiérrez, Ruperto Sanz Cantalapiedra, Luis M Quintero Gonzalez, Sara de Francisco Velasco, Miguel Angel Diez Garcia, Eva Sierra Quintana and Maria Cáceres. Torre Ramona Health Centre, Servicio de Salud de Aragon: Natividad González Viejo, José Felix Magdalena Belio, Luis Otegui Ilarduya, Francisco Javier Rubio Galán, Amor Melguizo Bejar, Cristina Inés Sauras Yera, Mª Jesus Gil Train, Marta Iribarne Ferrer and Miguel Angel Lafuente Ripolles. Primary Care Research Unit of Bizkaia, Basque Health Service-Osakidetza: Gonzalo Grandes, Alvaro Sanchez, Nahia Guenaga, Veronica Arce, Maria Soledad Arietaleanizbealoa, Eguskiñe Iturregui San Nicolás, Rosa Amaia Martín Santidrián and Ana Zuazagoitia.

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Gómez-Marcos, M.A., Patino-Alonso, M.C., Recio-Rodríguez, J.I. et al. Confirmatory factor analysis to assess the measure of adiposity that best fits the diagnosis of metabolic syndrome and relationship to physical activity in adults. Eur J Nutr 52, 1451–1459 (2013). https://doi.org/10.1007/s00394-012-0451-0

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